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Treatment Guidelines
v Adults & Adolescents
    (January 29, 2008)
v Pediatrics
    (February 28, 2008)
v Perinatal Guidelines
    (Nov 2, 2007)
v TB/HIV A Clinical Manual
PRODUCTS :: NRTIs :: DINOR
Therapeutic category: Anti-retroviral reverse transcriptase inhibitor

Composition:
DINOR
Each tablet contains: Didanosine 100 mg (buffered)

Indications and Usage:
Treatment of Human immunodeficiency virus in combination with other drugs.

Contraindications:
Hypersensitivity, peripheral neuropathy, pancreatitis, liver disease, alcohol abuse, and renal failure.

Pregnancy:
Should be used only where there are compelling clinical indications. Nursing mothers: mothers taking Didanosine should not breast-feed their infants.

Adverse reactions:
pancreatitis, lactic acidosis, severe hepatomegaly with steatosis, retinal changes and optic neuritis; and peripheral neuropathy;

Dosage and administration:
Adults: > 60 kg: 200 mg twice daily.
< 60 kg: 125 mg twice daily.
Dosage adjustments are required in renal insufficiency.

Presentation:
Tablets available as chewable buffered tablets.

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